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May 14, - New Zealand) sponsored trial of very low dose isotretinoin (5 mg/. day) for .. week double-blind, placebo controlled study of isotretin-. Mar 31, - Low dose isotretinoin was found to be a safe and effective choice for patients with moderate to severe .. A randomized double-blind study.Materials and Methods · INTRODUCTION · MATERIALS AND METHODS. NHS medicines information on isotretinoin capsules - what it's used for, side If you take the capsules twice a day and forget to take a dose, take it as soon as.